Job title: Research Associate Scientist (in vivo) – Bedford, MA
Company: PharmaEssentia
Job description: Job summary: (Position is located in Bedford, MA)
PharmaEssentia Innovation Research Center (PIRC) is seeking a Research Associate Scientist to join the Immunology and Pharmacology team and contribute to the development of novel immunotherapies for immunology and oncology in both clinical and pre-clinical programs. The successful candidate will be responsible for in vivo and ex vivo experiments to advance both exploratory and drug candidate discovery programs to support target validation, in-vivo efficacy, mechanism of action (MOA) and pharmacodynamic data essential to drive projects into clinical development. The ideal candidate will collaborate with other members of project teams and actively participate designing and conducting in vivo pharmacology models of immunology and oncology, as well as establishing early PK/PD for lead progression. This is a lab-based position and will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.
The Company:
It’s not often you get the chance to make a real impact on the lives of others, while expanding your own possibilities. You’ll find that rare opportunity at PharmaEssentia. Join us, and let’s transform lives, together.
PharmaEssentia Corporation is a rapidly growing biopharmaceutical innovator. We are leveraging deep expertise and proven scientific principles to deliver effective new biologics for challenging diseases in the areas of hematology, oncology and immunology, with one approved product and a diversifying pipeline. We believe in the potential to improve both health and quality of life for patients with limited options today through the combination of rigorous research and innovative thinking.
Founded in 2003 by a team of Taiwanese American executives and renowned scientists from U.S. biotechnology and pharmaceutical companies, today we are listed on the Taipei Exchange (TPEx: 6446) and are expanding our global presence with operations in the U.S., Japan, China and Korea, along with a world-class biologics production facility in Taichung.
Our new research center, PharmaEssentia Innovation Research Center (PIRC), will build upon our invention and discovery-based innovation efforts originally established in Taiwan that led to a transformative advancement for treating polycythemia vera (one of the myeloid proliferative neoplasms). At PIRC, we aim to expand our current expertise in related therapeutic areas and identify novel therapeutic approaches in early to mid-stage discovery and development. Data scientists will leverage artificial intelligence and machine learning to inform new target and indication selections. The company is also recruiting for talented scientists who have deep knowledge in immunology, translational science, bioinformatics and biologics platforms to develop novel drugs employing disease-driving biology, novel technology in protein engineering, antibody discovery and new modalities.
Summary of Key Responsibilities:
- Plan, coordinate and conduct in vivo and ex vivo studies across the different stages of preclinical drug discovery;
- Performance of rodent experiments including preparation of test samples, handling and dosing mice with various routes (SC, IP, IV or PO), collection of blood and tissues and mammalian immune cell functions;
- Collaborate extensively with other members of PIRC for protocol development and execution of studies in the immunology and oncology therapeutic area;
- Independently responsible for authoring animal protocols and ensuring their authorization and compliance;
- Data analysis and thorough documentation of work in the Company’s ELN system;
- Presentation of results in team meetings, other group settings;
- Working cross-functionally as part of internal multi-disciplinary project teams; and
- Maintaining a safe and clean vivarium and laboratory environment following all precautions required for a BSL2/BSL2+ setting.
Essential Qualifications:
- B.S./M.S. in immunology, biology, oncology or related discipline with 2-4 years of relevant academic or industry experience;
- Expertise in syngeneic or xenograft tumor models; PK/PD experience is a plus
- Hands-on experience in mammalian innate immune cell functions including macrophage, NK cells and so on;
- Familiar with human and murine primary cell isolation, cytokine profiling by ELISA or MSD or Luminex, T cells and myeloid cell functional assays. Experience in multi-color flow cytometry to evaluate immune cells function and data analysis software is a plus;
- Ability to follow defined procedures and protocols, and strong attention to detail;
- Willingness to learn new research methods and a desire for continued learning and development;
- Excellent organization and record-keeping skills;
- Demonstrated accountability and responsibility for own work; and
- Ability to work both independently and in a team setting.
Benefits of working with our team:
PharmaEssentia USA strives every day to improve the lives of patients as well as our employees.
As a valued member of PharmaEssentia USA, you will enjoy the following benefits:
- Comprehensive medical coverage
- Dental and vision coverage
- Generous paid time-off
- 401(k) retirement plan with competitive company match
- Medical & Dependent Care Flexible Spending Account
- Up to $150 monthly cell phone allowance
- Employee Assistance Program
EEO Statement:
At PharmaEssentia Innovation Research Center (PIRC), we are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. PIRC believes that diversity and inclusion among our team are critical to our success as a global company, and we seek to recruit, develop and retain the most talented people from a diverse candidate pool. PIRC does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any PIRC employees. PIRC is not responsible for any fees related to unsolicited resumes from staffing agencies.
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Expected salary:
Location: Bedford, MA
Job date: Sat, 06 Jan 2024 02:46:16 GMT
