Manchester City have been drawn for a tough away trip to Tottenham, while Chelsea face a daunting task against Aston Villa in the FA Cup round four.
The games between these Premier League giants are expected to be highlights of the round, with City, current champions of the title hoping to claim it again.
Other notable matchups for the round include Newcastle facing Fulham, while Manchester United potentially facing non-league opposition in Newport County or Eastleigh.
Liverpool will also draw either Norwich or Bristol Rovers for a home tie. the latter teams are in the Championship and League One respectively.
The full list of fixtures for the FA Cup fourth round is as follows:
Watford vs Southampton
Blackburn vs Wrexham
Bournemouth vs Swansea
West Brom vs Brentford/Wolves
West Ham/Bristol City vs Nottingham Forest/Blackpool
Leicester vs Hull/Birmingham
Sheffield Wednesday vs Coventry
Chelsea vs Aston Villa
Ipswich Town vs Maidstone
Liverpool vs Norwich/Bristol Rovers
Tottenham vs Manchester City
Leeds United vs Plymouth
Crystal Palace/Everton vs Luton/Bolton
Newport/Eastleigh vs Wigan/Manchester United
Sheffield United vs Brighton
Fulham vs Newcastle
